India's First Wine, Food and Hospitality Website, INDIAN WINE ACADEMY, Specialists in Food & Wine Programmes. Food Importers in Ten Cities Across India. Publishers of delWine, India’s First Wine.
Skip Navigation Links
About Us
Indian Market
Wine & Health
Wine Events
Retail News
Contact Us
Skip Navigation Links
Wine Tourism
Book Review
Photo Gallery
Readers' Comments
Video Wall
Media Partners
Ask Wineguyindia
Wine & Food
Wine Guru
Gerry Dawes
Harvest Reports
Mumbai Reports
Advertise With Us
US Report on Indian Market Released
Top Ten Importers List 2015-16
On Facebook
On Twitter
Delhi Wine Club

Posted: Friday, February 05 2010. 16:31

Possible Cure for Alcohol Intolerance

Researchers have discovered a compound that can repair a defective alcohol metabolism enzyme, a discovery published last month on the online edition of Nature Structural and Molecular Biology, suggesting the possibility of treatment for those affected by the inactive enzyme.

If you experience flushed cheeks, nausea and rapid heartbeat while drinking beer or wine, you are not alone but a part of a billion people in the word, most of them in East Asia. You cannot digest alcohol due to an inherent defective alcohol metabolism enzyme. You suffer from a particular type of alcohol intolerance; an inability to safely digest and metabolize alcohol.

For people like you, a genetic mutation produces an inactive form of the enzyme aldehyde dehydrogenase 2 (ALDH2), which is responsible for breaking down the toxic elements in a molecule of alcohol.

The researchers, working with the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and led by biochemistry and molecular biology professor Thomas D. Hurley of the Indiana University School of Medicine, have identified a molecule called Alda-1 that activates the defective enzyme when alcohol is present. It helps break down toxic compounds that could otherwise inflict damage on DNA.

This intriguing finding could have broad public-health implications," including treatments to reduce cellular damage during a heart attack.

Alda-1 binds to the structure of the inactive ALDH2 enzyme and allows the enzyme to metabolize alcohol as it would in someone who does not have the mutation. If this is developed into a treatment, the person could drink without alcohol intolerance side effects. Alda-1 could also have another use: fighting hangovers, the researchers say. Many hangover symptoms are due to aldehyde build-up, which ALDH2 can reduce.

If you are intrigued and still interested to know more, read details in Wine Spectator.

Want to Comment ?
Please enter your comments in the space provided below. If there is a problem, please write directly to Thank you.

Generate a new image

Type letters from the image:

Please note that it may take some time to get your comment published...Editor

Wine In India, Indian Wine, International Wine, Asian Wine Academy, Beer, Champagne, World Wine Academy, World Wine, World Wines, Retail, Hotel


Copyright©indianwineacademy, 2003-2020 |All Rights Reserved
Developed & Designed by Sadilak SoftNet